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The Research Behind Brightiva

The studies below represent published, peer-reviewed literature supporting the pharmacological rationale for each compound in the Brightiva formulation. 

Ketamine

Antidepressant effects of ketamine in depressed patients
Ketamine in clinical practice: transitioning from anesthetic agent to psychiatric therapeutic
Oral ketamine for depression: An updated systematic review
Oral ketamine may offer a solution to the ketamine conundrum
Ketamine in neuropsychiatric disorders: an update
Ketamine treatment for depression: a review
Ketamine as a prophylactic resilience-enhancing agent
Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis
Prophylactic Ketamine Attenuates Learned Fear

Dextromethorphan

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta) clinical use
Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status
Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder
Sigma-1 receptor: A potential target for the development of antidepressants
The sigma-1 receptor: a mechanistically-informed therapeutic target for antidepressants
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan

Fluoxetine

Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
Pharmacokinetics of selective serotonin reuptake inhibitors
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4
Description of the metabolism effects of ketamine, dextromethorphan, and fluoxetine when they are administered together – OpenEvidence.com

Ketamine & Substance Use Disorders

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review
Ketamine Treatment for Alcohol Use Disorder: A Systematic Review
A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial
Ketamine for the treatment of addiction: Evidence and potential mechanisms
Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial
Ketamine and Hydroxynorketamine as Novel Pharmacotherapies for the Treatment of Opioid Use Disorders

Additional research and clinical documentation is available to members inside the physician portal.